Cancer Cell metabolism

Cancer metabolism is based on the principle that cancer cells, as related to normal cells, have different metabolic activities in order to support their enhanced energy and anabolic requirements. The pioneering discovery by Otto Warburg in the middle of the 20th century led to the observation that metabolic activity in tumor tissues leads to a ten-fold increase in production of lactate (from glucose) under aerobic conditions. This revelation developed a significant interest and led industry stakeholders to target metabolic pathways in an effort to find the treatment of cancer. In addition, several academic players have also initiated studies to explore the functional consequences of alterations in various metabolic pathways.

  • Reactive oxygen species
  • Apoptosis
  • Cholesterol homeostasis and mitochondrial trafficking
  • Mitochondrial cholesterol trafficking in cancer

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