Call for Abstract

2nd Annual summit on Cell Metabolism and Cytopathology, will be organized around the theme “Emerging approach and innovations in the field of Cell Metabolism”

Cell Metabolism 2018 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Cell Metabolism 2018

Submit your abstract to any of the mentioned tracks.

Register now for the conference by choosing an appropriate package suitable to you.

Cells are regularly carrying out thousands of chemical reactions needed to keep the cell, and your body as a whole, alive and healthy. These chemical reactions are often linked together in chains, or pathways. All of the chemical reactions that take place inside of a cell are collectively called the cell’s metabolism.

To obtain a sense of the complexity of metabolism, let's take a look at the metabolic diagram below. To me, this mess of lines looks like a map of a very large subway system, or possibly a fancy circuit board. In fact, it's a diagram of the core metabolic pathways in a eukaryotic cell, essentially the cells that make up the human body. Each line is a reaction, and each circle is a reactant or product.

  • Track 1-1Adaptive physiology and the exercise response
  • Track 1-2Respiratory physiology and pathophysiology
  • Track 1-3Exercise Mimetics
  • Track 1-4Systemic mediators of exercise-induced health benefits
  • Track 1-5Exercise in Disease and Aging
  • Track 1-6Genetics, Epigenetics and Precision Medicine
  • Track 1-7Integrated omics and the adaptive response to exercise
  • Track 1-8Brain, heart, muscle & mitochondria
  • Track 1-9Exercise, stem cells and epigenetics
  • Track 1-10Airway cell biology and physiology

In biochemistry, a metabolic pathway is a combined series of chemical reactions occurring within a cell. The reactants, products, and intermediates of an enzymatic reaction are known as metabolites, which are modified by a sequence of chemical reactions catalyzed by enzymes. In a metabolic pathway, the product of one enzyme accomplishes as the substrate for the next. These enzymes often require dietary minerals, vitamins, and other cofactors to function. There are two types of metabolic pathways that are characterized by their ability to either synthesize molecules with the utilization of energy (anabolic pathway) or break down of complex molecules by releasing energy in the process (catabolic pathway). The two pathways complement each other in that the energy released from one is used up by the other.

  • Track 2-1Catabolic pathway
  • Track 2-2Anabolic pathway
  • Track 2-3Amphibolic pathway
  • Track 2-4Molecular mechanisms controlling muscle metabolic fitness
  • Track 2-5Molecular mechanisms of insulin signaling and insulin resistance
  • Track 2-6Metabolic effects of circadian disruption
  • Track 2-7Regulation of motile cilia in the airway
  • Track 2-8Epithelial ion transport and fluid secretion

Convenient metabolic regulation is essential for good health and well-being. The body is challenged on a daily basis with environmental and behavioral stresses that require adjustments in the type and quantity of fuels that oxidized for energy. When this ability to reciprocate to metabolic stress becomes impaired, it can lead to a number of diseases and disorders that are generally referred to as metabolic disease. Metabolic diseases affect a large proportion of the US population and have a substantial impact on the mortality rate and quality of life for afflicted individuals. Hence, many researchers are pursuing a better understanding of the underlying factors that lead to the development of metabolic diseases, the consequences of metabolic dysregulation, and the therapeutic strategies that can effectively counter the causes and consequences of this dysregulation.

  • Track 3-1Metabolic precision medicine
  • Track 3-2¬†circadian regulation of metabolism
  • Track 3-3¬†mechanism of obesity-associated insulin resistance and diabetes
  • Track 3-4¬†Nuclear receptor signaling in the developing and diseased heart
  • Track 3-5Retinal iron trafficking and its role in retinal disease
  • Track 3-6Energy homeostasis
  • Track 3-7Integrated energy metabolism
  • Track 3-8Translating therapeutics for metabolic diseases
  • Track 3-9Obesity
  • Track 3-10Diabetes
  • Track 3-11TDP-43 and amyloid beta precursor proteins (APPs) in health and disease

To scrutinize the interface between the nervous and immune systems during development, homeostasis, and disease. The meeting will examine the mediators, mechanisms, and implications of neuro-immune crosstalk in the central and peripheral nervous systems. It will also cover originating areas such as the neuronal regulation of peripheral immune function and the influence of the microbiota on the brain. We will bring together researchers from across the fields of neuroscience and immunology to facilitate discussion of exciting new concepts and developments in both fields.

  • Track 4-1Neuroimmune mediators in development and homeostasis
  • Track 4-2Mechanisms and therapeutics for age-related retinal neurodegeneration
  • Track 4-3Brain insulin signaling and dementia
  • Track 4-4CNS regulation of glucose
  • Track 4-5Neuroendocrinology of obesity
  • Track 4-6Neural control of peripheral immunity and inflammation
  • Track 4-7Peripheral immunity, inflammation, and infection in regulation of the brain
  • Track 4-8Blood brain barrier function and dysfunction
  • Track 4-9The Gut-Brain axis
  • Track 4-10Epigenomic regulation of transcription and metabolism by nuclear receptors

Human pathogenic viruses are regularly emerging and re-emerging, as highlighted by the recent Ebola outbreak in West Africa and the ongoing Zika virus outbreak in the Americas. By focusing on a range of human pathogenic viruses, this meeting will center on understanding and establishing common principles to help combat current and future viral threats. Starting with basic host-virus biology, the meeting will intent to ask how basic research can inform our understanding of emerging and re-emerging viruses to help with surveillance as well as vaccine and drug development. The meeting will bring infectious-disease researchers of many stripes together with scientists interested in the host response to these viruses from immunological, cell-biological, and pharmacological perspectives.

  • Track 5-1Genomics & Evolution
  • Track 5-2Emergence and Surveillance
  • Track 5-3Innate & Cellular Responses
  • Track 5-4Antibody Responses
  • Track 5-5Vaccines & Therapeutics

Immunologists study the immune system to asset human health, as a multitude of disorders, ranging from cancer to infectious, autoimmune and metabolic diseases, have an underlying basis rooted in immunity. While we have experienced important advances in immune-based therapies for many types of diseases in recent years, the complexity of human biology and the diversity that makes each of us unique mannerism outstanding challenges to translate basic knowledge into effective treatments. In addition, the technological advances and the advent of big data approaches also offer incredible opportunities to discover new biological principles that govern the functioning of the human immune system during homeostasis and disease.

  • Track 6-1Mapping the Human Immune System
  • Track 6-2Individuals and Populations: Understanding variation in the Immune System
  • Track 6-3Learning Mechanism from Human Disease
  • Track 6-4The human immune response to Cancer
  • Track 6-5From Mechanism to Vaccines and Back

The immune system has the unique capacity to merge with almost every tissue in the body to promote protection against threats and to preserve organismal homeostasis. Understanding how immune cells adapt their function to the needs of each distinct tissue environment is challenging. It requires thinking about immunity in the ambience of a whole organism, where immune function is integrated to other physiological systems – such as the nervous system, metabolic tissues and barrier sites – as well as to our meta-organismal partner: the microbiome.

  • Track 7-1The Meta-organism: microbiome and its host
  • Track 7-2Immunity at the epithelial barriers
  • Track 7-3The immune system and its neuro-metabolic interactions
  • Track 7-4Immunity in cancer and other diseased tissues
  • Track 7-5Technologies for discovery of novel immunological insights

The field of immunometabolism has flourished over the last decade, revealing not only the major roles played by immune cells in metabolic homeostasis but also the impact of metabolic pathways on immune cell function. As new discoveries continue to reveal the intricate links between immunology and metabolism, a key question arises: will our accumulated knowledge on immunometabolic deregulations translate into novel therapies for human diseases? In this topic will focus how local and systemic metabolism are integrated at the cellular level to regulate immune cell function and will focus on how novel insights into immunometabolism can be utilised to advance and/or bolster therapeutic interventions in metabolic diseases, inflammation, autoimmunity, and cancer.

  • Track 8-1Infection and host metabolic adaptation
  • Track 8-2Chronic inflammation and metabolic disease
  • Track 8-3Metabolic disruptions of immune cells
  • Track 8-4Cancer Immunity
  • Track 8-5Nutrient sensing and microbiome-host interactions
  • Track 8-6Regulation of gene expression and metabolism by nuclear hormone receptors
  • Track 8-7Respiratory mucociliary transport and innate immunity
  • Track 8-8Extra-oral taste receptors

Transcriptional Regulation in Development and Disease will import together researchers studying developmental biology and its disruption in disease with those examining the specific molecular and cellular mechanisms of transcriptional regulation.

  • Track 9-1Developmental dynamics
  • Track 9-2Transcriptional memory and plasticity
  • Track 9-3Non-coding RNAs and retroelements
  • Track 9-4Chromatin structure and epigenetics
  • Track 9-5Stem cells and developing systems
  • Track 9-6Tools and techniques for in vivo analysis
  • Track 9-7Cardiovascular metabolism
  • Track 9-8Epithelial ion and fluid transport

As organisms age, switch over time occurs as a layered process, from molecular modifications to shifts in tissue homeostasis, ultimately leading to systemic transformations. Alterations in metabolism are found throughout the hierarchy of change and can be integral to the relationship between aging and disease as well as to the impact of aging on physiological processes such as inflammation and immunity.  Recent studies have contributed new insight into how the perturbation of metabolic factors can accelerate or impair aging processes.  Furthermore, there is a growing appreciation for the role of aging in the immune response and the need to take this phenomenon into account when considering therapeutic approaches, from vaccines to precision medicine.  It is an exciting time to consider the multifactorial nature of aging, the new biological discoveries being made, and how to translate these insights to human health as longevity reaches unprecedented levels worldwide.

  • Track 10-1Cellular and molecular aging
  • Track 10-2Metabolism and aging
  • Track 10-3Inflammation and aging
  • Track 10-4Interventions
  • Track 10-5Aging and immunity in humans
  • Track 10-6Role of lipid droplet proteins in lipid and glucose metabolism
  • Track 10-7Role of myokines in glucose and lipid metabolism
  • Track 10-8Bicarbonate secretion and intracellular pH regulation

Cancer metabolism is based on the principle that cancer cells, as related to normal cells, have different metabolic activities in order to support their enhanced energy and anabolic requirements. The pioneering discovery by Otto Warburg in the middle of the 20th century led to the observation that metabolic activity in tumor tissues leads to a ten-fold increase in production of lactate (from glucose) under aerobic conditions. This revelation developed a significant interest and led industry stakeholders to target metabolic pathways in an effort to find the treatment of cancer. In addition, several academic players have also initiated studies to explore the functional consequences of alterations in various metabolic pathways.

  • Track 11-1Reactive oxygen species
  • Track 11-2Apoptosis
  • Track 11-3Cholesterol homeostasis and mitochondrial trafficking
  • Track 11-4Mitochondrial cholesterol trafficking in cancer

Molecular imaging of tumor metabolism has obtained considerable interest, since preclinical studies have indicated a close relationship between the activation of various oncogenes and alterations of cellular metabolism. Furthermore, several clinical trials have shown that metabolic imaging can significantly impact patient management by improving tumor staging, restaging, radiation treatment planning, and monitoring of tumor response to therapy. In this topic includes recent data on the molecular mechanisms underlying the increased metabolic activity of cancer cells and discuss imaging techniques for studies of tumor glucose, lipid, and amino acid metabolism.

  • Track 12-1Glucose metabolism
  • Track 12-2Amino acid metabolism
  • Track 12-3Optical imaging
  • Track 12-4Lipid metabolism
  • Track 12-5PET
  • Track 12-6Transcriptional and epigenetic control of mitochondrial function
  • Track 12-7Transcriptional and epigenetic control of mitochondrial function

Cancer cells display critical metabolic transformations induced by mutations that result in cell cycle deregulation associated with enhanced cellular stress. Adaptation to this stress phenotype is required for cancer cells to survive and involves the participation of genes that regulate metabolism, bioenergetics, cell death and ROS detoxification. In this text, small molecules that selectively kill cancer cells while sparing normal surrounding cells, are the desired approach for the treatment of cancer. To this aim, cancer therapeutics should target the differential features of cancer cells. Here, we briefly summarize the therapeutic strategies that involve mitochondria and their proposed mechanism of action to selectively target transformed cells.

  • Track 13-1Therapeutics targeting cancer cell death
  • Track 13-2Therapeutics aimed at cancer metabolism and bioenergetics
  • Track 13-3Therapeutics targeting cancer cell ROS sensitivity

Cytopathology is a branch of pathology that studies and diagnoses diseases on the cellular level. The discipline was founded by George Nicolas Papanicolaou in 1928. Cytopathology is generally used on samples of free cells or tissue fragments, in contrast to histopathology, which studies whole tissues. A cytopathologist is an anatomic pathologist trained in the diagnosis of human disease by means of the study of cells obtained from body secretions and fluids by scraping, washing, or sponging the surface of a lesion, or by the aspiration of a tumor mass or body organ with a fine needle. A major aspect of a cytopathologist’s practice is the interpretation of Papanicolaou-stained smears of cells from the female reproductive systems. However, the cytopathologist’s expertise is applied to the diagnosis of cells from all systems and areas of the body. The cytopathologist is a consultant to all medical specialists.

  • Track 14-1Exfoliative cytology
  • Track 14-2Intervention cytology
  • Track 14-3Sediment cytology
  • Track 14-4Fine-needle aspiration